| Rank | seized | Place | Year | Total Value |
|---|---|---|---|---|
| 1 | 1,080 pounds of heroin |  San Francisco |
1991 | $2.7 billion to $4 billion |
| 2 | 17.5 tons of poppy seeds |  Afghanistan |
2008 | $1.3 billion |
| 3 | 14 tons of cocaine |  Colombia |
1984 | $1 billion |
| 4 | 27 tons of cocaine | Colombia |
2007 | $500 million |
| 5 | 21 tons of cocaine |  Mexican |
1989 | $350-$450 Million |
Police raided Zhenli Ye Gon's home (Mexico) in March, carting off what they said was $207 million
;